Lecture Schedule

Didactic Lectures

Introduction to Modern Neuroscience

   June 10 Leifer Methods for measuring neuronal signals
   June 11 Berry Electrochemistry, V-clamp, gNa, gK, Hodgkin-Huxley model
   June 12 Wang
Synaptic transmission, the first 10,000 milliseconds
Plasticity and learning rules
   June 13 Berry
Integrate and fire model, slow conductances, bursting, bistability
Molecular neuroscience
   June 14 Falkner
Subcortical circuits for innate behavior
Quantitative methods for animal behavior

Molecular Methods for Identifying and Targeting Defined Neural Populations

   June 17 Murthy Genetic tools for systems neuroscience
   June 18 Buschman Dynamics of cognitive control
   June 19 Witten
Optical dissection of reward circuits
Noon talk on Ethical Conduct of Research (lunch provided)
   June 20 Tank
Sequence generation & place cells: experiments and models
Noon talk on Research Reproducibility (lunch provided)
   June 21 Gould Hippocampus and plasticity through the lifespan

Structural Neurobiology & Connectomics

   June 24 Wanner Computational Connectomics
   June 25 Engel Viral vectors for circuit exploration
   June 26 Ghazanfar Developmental neuromechanics of vocal communication

Large Scale Recording Technology

   June 27 Brody Models of persistent neural activity and attractor networks
   June 28 Berry Electrode array recordings to study retinal dynamics

Models of Information Processing

   July 1 Bialek Statistical mechanics for networks of real neurons
   July 2 Pillow Scalable models for high-dimensional neural data

Human Neuroscience Methods

   July 3 Norman
Cognitive neuroscience of learning and memory
Comparative electrophysiology in human and non-human primates
   July 4 Rinberg (NYU) Computational olfaction
   July 5 Cohen Neural mechanisms for decision making and cognitive control

Laboratory Exercises

   June 10 Intracellular recording, synaptic physiology I
   June 11 Intracellular recording, synaptic physiology II
   June 12 Short-term potentiation (STP); facilitation I
   June 13 Short-term potentiation (STP); facilitation II
   June 14 Sensory Receptors: Crayfish Muscle Receptor Organs
   June 17 H1 motion sensing neuron in blowfly I
   June 18 H1 motion sensing neuron in blowfly II
   June 19 H1 motion sensing neuron in blowfly III
   June 20 Optogenetics of the Drosophila song pathway I
   June 21 Optogenetics of the Drosophila song pathway II
   June 24 Multi-neuron dynamics: Rotations
   June 25 Multi-neuron dynamics: Rotations
   June 26 Multi-neuron dynamics: Rotations
   June 27 Multi-neuron dynamics: Rotations
   June 28 Multi-neuron dynamics: Rotations
   June 29 Short talks to the class by each rotation group

Student rotations in Recording multi-neuron dynamics will be chosen from the following:

  1. Berry Lab: two-photon calcium imaging from neural populations in the primary visual cortex to explore long-time scale dynamics
  2. Tank lab: Multi-neuron imaging in mouse cortex during decision making
  3. Brody lab:  A new optogenetic approach for silencing neural populations during decision making in rats
  4. Wang lab:  Miniscope calcium imaging in freely moving mice in conjunction with automated pose classification
  5. Witten lab: Dopamine neurons in medial and lateral VTA modulate fear extinction with distinct temporal profiles
  6. Pillow lab: Extending Generalized Linear Models to structured and high-dimensional data
  7. Falkner lab: Spike time analysis of hypothalamic sub-circuits that are engaged during mouse social interaction across multiple brain regions
  8. Gelperin/Thiberge lab: In vivo two-photon recording of neural populations in zebra fish
   July 1 – 5 Independent Projects and Introduction to fMRI imaging

Students will formulate a proposal for an Independent Project in consultation with one or more members of the program faculty, culminating in a one page written proposal outlining the rationale for the proposed project, the methods for obtaining quantitative date relevant to the question posed in the proposal and the analysis methods to be applied to the data obtained during the proposed work. Program faculty will help the student to evolve a proposal that asks an interesting and important question and is practical given the time and instrumentation limitations. A substantive report detailing the results of the Independent Project is required.

A lecture and demonstration of fMRI imaging will be scheduled during this period.